I got into Cowboy Action competition shooting several years ago. The Ruger Vaquero is very popular amongst that group. We like to match our pistol caliber to our rifle caliber so we can use the same ammo for both. I have a Marlin Cowboy lever action in 357/38sp. I bought these two Vaqueros in 357/38sp. We shoot approximately 100 rounds pistol, 100 rounds rifle and 50 rounds shotgun in one shoot so price becomes an immediate challenge. 45 Colt is very expensive to buy in cowboy loads or to reload yourself at that volume so 38spl became the most popular caliber as reloading components are cheaper. Something to consider if you shoot a lot. You can't beat the Ruger Vaquero. It's a great pistol.