I realize that a 12 gauge is not a handgun, which was the focus of this thread. That said, I also know that my 870 with Federal Tru Ball Deep Penetrator (2 3/4") slugs will go through the skull of a 200 lb hog at 30 yards... and keep going. Hog was a hard quartering-to shot, almost looking straight at me. Slug was found lodged under the hide over half way back on the off-side ribs. After punching through the skull of the hog, it traveled about 2' through meat and bone to get to its resting point. The shot was made from an elevated stand, so I was in no danger. The gun and the ammo will do the trick. Finding oneself in a less than ideal situation of being startled by a creature 4x or more the weight of that hog, and with ill intent may lead to a completely different ending.